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  • About
    • Our Approach
    • About Dr Hagmeyer
  • Conditions We Help
    • Cardiovascular Health
      • CardioMetabolic Health
      • Cardiovascular Disease
    • Functional Medicine
    • Gut Health
      • Acid Reflux GERD
      • Candida and Yeast Overgrowth
      • Food Sensitivity
      • Gluten
      • Gut Dysbiosis
      • IBS
      • Leaky Gut
      • Psoriasis
      • SIBO
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      • Chronic Fatigue Syndrome
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      • Women’s Health
        • Estrogen
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      • Immune System Disorders
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      • Mold and Biotoxin Illness
      • Overactive Immune System
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The Most Comprehensive Stool Test for Optimal Clinical Utility

New GI Effects Reporting Enhancements

Genova Diagnostics is pleased to announce innovative reporting enhancements to the GI Effects Comprehensive and GI Effects Microbial Ecology stool profiles.

New Features Include:

A Commensal Balance Infographic – Designed to provide a more precise view of an individual patient’s commensal bacteria (PCR) results relative to a spectrum of healthy and unhealthy commensal patterns. (See video featured below.) It is a composite of two measures:

  • The Healthy-Pattern Continuum (formerly known as the Diversity Association Index) is a progressive ranking scale based on a Genova proprietary algorithm that differentiates healthy and unhealthy commensal patterns. This algorithm is applied to an individual patient’s GI Effects commensal bacteria (PCR) findings, and produces a numeric result ranging from 0 to 10. It is denoted by the ‘y’ axis of the Commensal Balance infographic.
  • The Reference Variance Score reflects the total number of an individual patient’s commensal bacteria (PCR) results that are out of reference range. This number ranges from zero to 24, and is denoted by the ‘x’ axis of the Commensal Balance infographic.

When Should the GI Effects Comprehensive Stool Profile Be Considered?

The GI Effects Comprehensive Stool Profile can reveal important information about the root cause of many common gastrointestinal symptoms such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation. This stool analysis utilizes biomarkers such as Calprotectin to differentiate between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).3,4

In addition, Genova’s GI Effects test can be used to evaluate patients with a clinical history that suggests a gastrointestinal infection or dysbiosis.

Gut microbes are codependent with one another and with their human host, and the health of one affects the other. A sizeable volume of research associates a dysbiotic, or imbalanced gut microbiome with multiple disease states both within and outside of the GI tract.1,2 The diverse metabolic activities of the microbiome ultimately impact the human host, and the activities of the human host ultimately affect the health of their microbiome.

What is the GI Effects Comprehensive Stool Profile?

The GI Effects® Comprehensive Stool Profile is an advanced stool test that provides immediate, actionable clinical information for the management of gastrointestinal health. Utilizing cutting-edge technologies and biomarkers, this test offers valuable insight into digestive function, intestinal inflammation, and the intestinal microbiome.

The biomarkers from the GI Effects Comprehensive Profile are reported using the DIG framework, providing key clinical information for three main gastrointestinal functional areas:

  • Digestion/Absorption:
    • Pancreatic Elastase-1 is a marker of exocrine pancreatic function.
    • Products of Protein Breakdown are markers of undigested protein reaching the colon.
    • Fecal Fat is a marker of fat breakdown and absorption.
  • Inflammation/Immunology:
    • Calprotectin is a marker of neutrophil-driven inflammation. Produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).3,4
    • Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response.
    • Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.
  • Gut Microbiome:
    • Metabolic indicators, including short-chain fatty acids and beta-glucuronidase, demonstrate specific and vital metabolic functions performed by the microbiota.
    • Commensal Bacteria demonstrate the composition and relative abundance of gut organisms.
      • More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques.
      • GI Effects assesses a set of 24 genera/species that map to 7 major phyla.
    • Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms.
    • Bacteria and mycology sensitivities are provided for pathogenic or potentially pathogenic organisms that have been cultured. The report includes effective prescriptive and natural agents.
    • Parasitology
      • GI Effects provides microscopic fecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
      • Enzyme immunoassay (EIA), widely recognized for its diagnostic utility in the detection of pathogenic antigens, is used for the identification of Cryptosporidium, Entamoeba histolytica, and Giardia lamblia.
      • Selection of a one-day or three-day sample collection is based on clinician’s clinical index of suspicion for parasitic infection. If there is no/low suspicion, a one-day sample will likely be adequate. For high suspicion, a three-day sample collection is optimal.
  • Additional Biomarkers Available:
    • Campylobacter
    • Clostridium difficile
    • Escherichia coli
    • Fecal Lactoferrin
    • Helicobacter pylori
    • Macro Exam for Worms
    • Stool Zonulin
    • KOH Preparation for Yeast

What Advantage Does the Profile Offer Compared to Other Diagnostics?

A structured fecal biomarker panel offers the advantage of assessing multiple functional areas that may be contributing to symptoms. For example, diarrhea could stem from multiple causes including pancreatic exocrine insufficiency, inflammation, food allergies, or the presence of a pathogenic or potentially pathogenic organism. A positive result on one or more fecal biomarker tests may guide therapy, either by suggesting a treatable alternative diagnosis or by eliminating a diagnosis from further consideration. The latter allows individualized targeted treatment to be redirected to more likely diagnoses.5,6

GI Effects® represents the best technical platform to assess gut health, including an anaerobic bacteria PCR molecular assay, Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for cultivable species identification, as well as stool-based biomarkers for gastrointestinal diagnostics.

What Can Clinicians and Patients Expect from GI Effects Comprehensive Profile Stool Testing?

The GI Effects Stool Profile biomarkers provide comprehensive information for the development of strategic interventions. Symptoms often improve as identified functional imbalances and inadequacies become normalized through targeted dietary, lifestyle, and supplementation therapeutics.


References

  1. Marchesi J, et. al. The gut microbiota and host health: a new clinical frontier. Gut. 2016 Feb;65(2):330-9.
  2. Clemente J, et. al. The impact of the gut microbiota on human health: an integrative review. Cell. 2012 Mar;148(6):1258-70.
  3. Menees SB, et. al. A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS. Am J Gastroenterol. 2015 Mar;110(3):444-54.
  4. Dabritz J, Musci J, Foell D. Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome. World J Gastroenterol. 2014 Jan;20(2):363-375.
  5. Parsons K, et. al. Novel testing enhances irritable bowel syndrome medical management: the IMMINENT study. Glob Adv Health Med. 2014 May;3(3):25-32.
  6. Goepp J, et. al. Frequency of abnormal fecal biomarkers in irritable bowel syndrome. Glob Adv Health Med. 2014 May;3(3):9-15.

The entire contents of this website are based upon the opinions of Dr. Richard Hagmeyer unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Hagmeyer and his community. Dr. Hagmeyer encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Hagmeyer products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products. Copyright © 2022 Dr. Hagmeyer · All Rights Reserved · Powered by drhagmeyer.com

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