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We know how frustrating it can be to struggle with Histamine Intolerance and MCAS Symptoms. If you are like most patients you have been on the medical merry go round, bouncing from one doctor to the next. There are many reasons for Histamine Intolerance and MCAS. Let us provide you with the answers you are searching for.

Symptoms Commonly Experienced with Histamine intolerance/MCAS:

• Dizziness or vertigo
• Asthma- Wheezing, labored breathing
• Irregular or quickened heart rate
• Migraines and/or chronic headaches
• Light sleeping and difficulty going to sleep
• Sinus discomfort including congestion, sneezing

• Cramps
• Anxiety
• Fatigue
• Hypertension
• Nausea, vomiting
• Hives and/or flushing

Is Histamine Intolerance Making You Sick?

Histamine intolerance is often accompanied by unexplained symptoms such as an itchy tongue and runny nose while eating certain foods such as banana, avocado, or eggplant. Sometimes patients experience a flushed face when drinking red wine, unpredictable menstrual cycles, or unusual headaches & anxiety. Any of these symptoms could be linked to histamine intolerance.Histamine is a chemical that acts as a neurotransmitter, sending information between your body and your brain. It is also a key player in immune system, central nervous system, as well as your digestive tract. Histamine is found in your stomach acid so it has a role in breaking down food as well.However histamine is most commonly thought of in relation to the immune system and seasonal and/or food allergies. Histamine causes a sudden and rapid inflammatory response, setting off an alarm within the immune system that invaders are present. As a result, white blood cells are called upon to swiftly identify and eliminate the foreign bodies. It is the quick flood and build up of histamine that can cause symptoms such as headache, itchiness, flushed face, and overall feeling inflamed and uncomfortable.Histamine works through your bloodstream so high levels that aren’t broken down can potentially harm not only your gut but your lungs, brain, skin, and cardiovascular system. It is for this reason that symptoms can vary from person to person.

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• How to start a Low Histamine Diet
• Foods to Eat on A Low Histamine Diet
• Foods To Avoid on Low Histamine Diet
• Medications that can Cause Histamine Intolerance
• Common Mistakes made on a Low Histamine diet
• More..

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Histamine Intolerance and MCAS Disease

Don’t underestimate just how powerful lifestyle modification, Natural medicine, dietary changes and Functional medicine can be when it comes to restoring thyroid function.

01

Histamine and Eczema

In addition to the symptoms listed above, excess histamine can make some existing conditions worse. Eczema is an example. Eczema is an inflammatory condition in the skin, sometimes called atopic (allergic) dermatitis. When high histamine foods are consumed, people with less than efficient histamine tolerance may experience an increase in the severity of their eczema.

02

Histamine and SIBO

SIBO is an intestinal motility disorder that leads to an overgrowth of good or bad bacteria in the small intestine, where few bacteria belong. There are many causes of SIBO however diets high in sugar and refined carbs, antibiotics or other medications that disrupt your delicate microbiome, or physical obstructions in the gut such as scarring from surgeries or Crohn’s disease.

03

Histamine and Estrogen

The complexity of histamine intolerance extends to the interaction between histamine, estrogen and progesterone in the female body. Mast cells are a key factor underlying these interactions, with the presence of both estrogen and progesterone receptors on mast cells. The binding of estrogen to mast cell receptors stimulates the expression of H2 and H3 receptors, and induces rapid histamine degranulation, synthesis and release. Estrogen can also influence endogenous histamine levels by down regulating DAO activity. This ultimately leads to high histamine levels in the body.

04

Histamine and The Brain

Having excess histamine goes way above and beyond your typical allergy symptoms. Excessive histamine can also wreck havoc on the brain. Histamine has been shown to play a pivotal role in many psychiatric disorders such as depression, schizophrenia, anxiety. Because histamine plays a role in wakefulness of the brain, too much histamine can overstimulate the brain leading to anxiety and insomnia as well as restlessness. Any unbalance in the chemical makeup of your brain is bound to cause unwanted effects. These side effects can vary drastically from person to person depending on what Histamine receptor (H1,H2,H3,H4) is stimulated. Brain fog, fatigue, and anxiety are all too common for people who suffer with MCAS and histamine intolerance.

Causes of Histamine Intolerance

Histamine intolerance is caused by the bodies decreased ability to breakdown histamine. The next question we should be asking is, “what would interfere with the bodies ability to do this?” Over loaded histamine levels are brought on by a number of factors.

• Gut Dysbiosis
• Small Intestinal Bacterial overgrowth (SIBO)
• GI bleeding/Inflammation (Ulcers, Crohn’s)
• Estrogen Dominance, Low Testosterone

• Certain Amino Acids ie Histidine
• Histamine Rich foods such (see list below)
• Memory lapses
• Mold Biotoxins (CIRS)
• Stress, High Cortisol Levels (Adrenal Gland Dys-regulation)

• Leaky gut syndrome
• Food sensitivities
• Mold Allergies
• Genetic mutations or SNP’s- can prevent the break down of histamine as well.

Histamine Stress, Panic attacks and Heart palpitations

Histamine receptors are found all throughout the body and as a result, histamine intolerance affects each of us in different ways. The symptoms that present themselves vary based on which of the four histamine receptors are being activated (H1, 2, 3, 4), and where. In the heart, histamine functions as a vasodilator, meaning that it widens our blood vessels, and therefore there is less resistance to blood pumping through the body this causes a drop in blood pressure.

Have You Stopped to Ask

Treating Histamine Intolerance

Identifying individual food sensitivities, Food Allergies, Eliminating all foods high in histamine for 4-6 weeks or longer depending on circumstances, is the best place to start. It’s also important to uncover why the intolerance is present in the first place; this is where functional medicine can truly make a difference. Perhaps the underlying cause is gut dysbiosis, SIBO, gluten intolerance, Hormones (Estrogen/Thyroid) Mold allergies, Mold Bio-toxins (CIRS), leaky gut, or a course of medication you’ve been taking.Addressing the root cause of histamine intolerance, shifting the diet, improving gut microbiome, and replenishing DAO levels naturally help get the body back on track.At DrHagmeyer.com, we strive to fully understand the needs and concerns of our patients and we will work closely with you to ensure your good health is restored. To help ensure your health is improved, we offer extensive testing and customized treatment programs as well as an overriding dedication to helping you get better.

WHY YOU SHOULD CONSULT WITH A DOCTOR WHO IS

Certified in Functional Medicine and Has over 20 Years of Experience

We know that successfully managing Histamine Intolerance and MCAS takes more than just taking antihistamines. That’s why we focus on the whole person and the root causes behind your symptoms. Once you download my free E-book, on the Next page, you will gain access to a several videos that I think you will find incredibly helpful. Treating Histamine intolerance and MCAS is complex. If you are not feeling better, don’t beat yourself up. Successful treatment and management require a whole person approach. Start today by downloading the free histamine E-book and watch the videos on the next page.

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Download this E-book today. Then watch the videos on the next page.