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The Food Opiods: Caseomorphins and Gluteomorphins

Is Your Food Causing You To Be High?
The Food Opiods: Caseomorphins and Gluteomorphins

These morphine-like substancesCasomorphin and Gluteomorphin, are derived from dairy and wheat respectively, are critical to our understanding of the power of these two foods in our health and well-being.

Autistic children are very addicted to wheat and dairy, which is consistent with the tenet that we become addicted to what will make us ill (cigarettes, drugs, alcohol and food ). There are no healthy addictions and food is no exception. If an individual feels that they cannot give up diary, cheese or bread, then they are very likely to be having a problem with one of these foods. Withdrawal from these foods can (in certain individuals) lead to classic drug-withdrawal symptoms. If this sound familiar,  you might have problems with Gluteomorphins and Casomorphins. 


Gluteomorphin, also known as, Gliadorphin, is an opioid peptide formed from undigested Gliadin from gluten protein. In the brain, Gluteomorphins can directly interfere with neuronal messaging by binding to the opioid receptors thus inhibiting the natural binding of neurotransmitters to their receptors.

In addition, lymphocytes carry the same receptors on their own surfaces; therefore, Gluteomorphins can indirectly interfere with opioid receptors through lymphocyte secretion of cytokines and cause the delivery of wrong messages to the brain.

If antibodies are produced to Gluteomorphin, these antibodies act like the natural opioids, on the lymphocytes and the nerve cells causing neuro-immune abnormalities. Thus, Gluteomorphins can disturb neuro-immune communication through neurotransmitters and cytokines.

These Gluteomorophin antibodies appear

  1. Autism
  2. Celiac Disease
  3. non Celiac Gluten Sensitivity


Caseomorphins are the proteins that make up 80-90% of the protein content of cow’s milk and are formed during our attempt to digest casein. It is this same protein that can cause damage to the lower intestinal lining and a malabsorption syndrome similar to that seen in celiac disease, or gluten intolerance. One of the main proteins found in gluten grains is gliadin. Gluteomorphins are derived from gliadin.

Wheat/Gluten Sensitivity and Autoimmunity 1

These Casomorphin antibodies appear

  1. Autism
  2. Celiac Disease
  3. non Celiac Gluten Sensitivity

What you should Remember

  • These morphine-like psychoactive peptides results from the incomplete digestion of these gluten containing dietary proteins.
  • These protein bind to the opiate receptors in the brain.
  • Psychiatric reactions to these gluten proteins, including the sense of “brain fog” behavioral problems, or mood swings that often accompany immune reactions to these foods and which may follow with panic attacks, depression, or other neurological complaints.
  • Both Gluteomorphins and Casomorphins are morphine-like opiods that have been likened to drugs like LSD.
  • They can be very sedating and addictive and help to explain why 75% of the calories in the standard American diet (S.A.D.) come from wheat and dairy alone. Food addiction is a very real thing and these opiods play a huge role. 
  • These sedating compounds are also the single biggest contributing factor to post-meal drowsiness. 
  • In the next several years, more and more doctors will become familiar with these two terms. Unfortunately, even most doctors have no idea what these substances are and how much they can affect a person. How can something that plays such a vital role in the lives of the multitudes, contributing to autistic symptoms, food addiction, clinical depression, chronic fatigue, caffeine addiction, highway deaths, and more go without being learned and kept in the forefront of the minds of all doctors? Something to consider? 

What’s Next?

When a patient has intestinal dysfunction or intestinal permeability, these small, undigested molecules may enter the blood stream, and, if blood-brain barrier permeability exists, pass through the blood- brain barrier. In the brain, Gluteomorphins can directly interfere with neuronal messaging by binding to the opioid receptors thus inhibiting the natural binding of neurotransmitters to their receptors. If you tested positive for either of these, it may be time to get your barriers tested.

  1. Blood Brain Barrier Testing
  2. Intestinal Barrier Testing aka Leaky Gut

To find out what may be affecting you and causing symptoms similar to those stated above, contact our office.


  1. Chavkin, et al. Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus. J Neurosci, 1985; 5(3):808-816.
  2. Cosford. PANDAS (pediatric autoimmune neuropsychiatric disease associated with Streptococcus) in autism? Electronic J Appl Psychol, 2009; 5(1):39-48.
  3. Gardner. Exorphins and other biologically active peptides derived from diet. Brostoff and Challacombe (eds) Food allergy and intolerance (2nd edition). Saunders: New York; 2002.
  4. Northrop. Endogenous and exogenous regulation and control of physiological systems. Chapman and Hall/CRC: Boca Raton, FL; 1999.
  5. Roy, et al. Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer’s disease, multiple sclerosis, and advanced HIV infection. Biol Psychiatry, 1994; 35:335-344.
  6. Vojdani, et al. The immunology of gluten sensitivity beyond the intestinal tract. Eur J Inflammation, 2008; 6(2):47-57.
  7. Vojdani, et al. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci, 2004; 7(3):151-161.
  8. Vojdani, et al. Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. Intl J Immunopathol Pharmacol, 2003; 16(3):189-199.
  9. Pruimboom and de Punder. The opioid effects of gluten exorphins: asymptomatic celiac disease. J Health Population Nutr,

2015; 33:24.


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