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What Are Lipopolysaccharides, And How LPS Toxins Affect Thyroid Health?

August 25, 2014 //  by Dr Hagmeyer

LPS Bacteria- Lipopolysaccharides

Lipopolysaccarides (LPS) are present in the cell walls of gram-negative bacteria. While their primary function is to protect the cell membrane, when the bacteria die, the LPS get released and can cause many problems, particularly in people who have thyroid and autoimmune thyroid disorders like Graves’ Disease and Hashimoto’s Thyroiditis.

When this happens, the patient is at greater risk of developing inflammatory response diseases including Depression, Anxiety and Brain fog, symptoms most people who suffer with either Thyroid problems or Gastrointestinal problems are already familiar with.

Learn more about a Natural 10 step approach to supporting your thyroid disorder here.

Effects of LPS activation

All kinds of bacteria are always present in the body and the body’s immune system usually fends off most attacks. However, when the bacteria dies, the LPS still has a residual effect and can cause:

  • Fever
  • Leukocytosis (high blood cell count)
  • Low iron levels
  • Blood clotting disorders
  • Thrombocytopenia (Low Platelets)
  • Platelet aggregation

But it does not stop here. LPS is also a factor in leaky gut syndrome since it increases intestinal permeability. Leaky gut is a distressing disorder and if a person has high levels of LPS, the risk of developing leaky gut increases. This in turn increases the risk of devleoping Graves’ disease, Hashimoto’s Thyroiditis and other autoimmune disorders.

There is actually a test that shows increased intestinal permeability as it checks for increased antibodies against LPS. Carried out by Cyrex Labs, this test measures LPS in the blood stream, pointing to the likelihood of leaky gut syndrome.

More details of the test for a Leaky Gut

The test, called Intestinal Antigenic Permeability Screen, carried out by Cyrex Labs investigates three types of antibodies, including Actomyosin antibodies, Occludin/Zonulin antibodies and LPS.  Both the Actomyosin and Occludin/Zonulin antibodies directly relate to the presence of a leaky gut.  High levels of the first two lead the doctor to conclude that the person has leaky gut syndrome.

Also increased LPS show that there is an imbalance of the gut flora (intestinal dysbiosis) that is often found in patients of leaky gut syndrome. It is possible that though the first two levels are negative, but the LPS are positive, the intestinal dysbiosis is present though there is no leaky gut.  If the patient has suppressed immunoglobulins, the results can even be false negative.

Intestinal dysbiosis can also be caused by antibiotic treatment, chronic high stress and even food allergens. After all, Lipopolysaccharides are endotoxins present in gram-negative bacteria, and only released when the gram-negative bacteria die.

Causes of Intestinal Disbiosis and Leaky Gut

LPS has varied effects on the body. It can have a negative effect on thyroid health, causing the leaky gut that, in turn, causes an autoimmune thyroid condition. LPS may have an effect on the hypothalamic-pituitary-thyroid axis.  It is the hypothalamus that produces thyrotropin-releasing hormone (TRH); this stimulates the pituitary gland to secrete TSH and TSH is responsible for the thyroid gland secreting thyroid hormones.

LPS affects pituitary and thyroid functions, secretion in follicular cells, decreasing thyroid function, either by affecting the pituitary gland or the thyroid gland cells directly. The T4 levels may seemingly go down, but T4 conversion to T3 does not decrease simultaneously.

Lipoploysaccharides can cause lots of problems – they increase in intestinal dysbiosis, reduce immunity, lead to increased risk of developing inflammatory conditions and can result in a leaky gut. All these aggravate an auto immune response that can lead to Graves’ Disease, Hashimoto’s Thyroiditis and imbalance in the hypothalamic-pituitary-thyroid axis.

Our Personal Thyroid Recovery Program is Tailored and Customized to the Individual.

Book-Cover-For-Pageno-reflectionThe Personal Program Thyroid Recovery Program is a Natural Treatment for Low Thyroid function, Hypothyroidism, Hyper thyroidism and Hashimoto’s problems. Our office utilizes nutritional supplements, Dietary modifications, Hormone and endocrine support formula, and lifestyle guidance.

  1. To Schedule a Free 15 minute Phone Consult to see if this program is right for you. Fill out our online questionnaire.
  2. If you’re ready to get started and schedule an appointment take a moment and fill out our contact us form and in the comment box let us know what time of the day works best to contact you. One of our New Patient Coordinators will contact you with the next available new patient opening within 24-48 hours. You can also call us at 630-718-0555
  3. Still have questions? Our Free 15 minute personalized Phone consult is a great place to start.

We’re here to listen and help you through this frustrating and confusing time.

Each person suffering with Thyroid symptoms problem has a different set of mechanisms or causes. Our office will customize a Thyroid Restoration Program based on your testing and tailored to your individual needs.

Category: Gut, Hashimotos, Hormone, Leaky GutTag: hashimoto, leaky-gut

Previous Post: «Adrenal Fatigue-Is It All In Your Head? Or Is Your Doctor Just Clueless Adrenal Fatigue-Is It All In Your Head? Or Is Your Doctor Just Clueless
Next Post: 10 Reasons Why It Seems Impossible To Stabilize Your Thyroid. 10 Reasons Why It Seems Impossible To Stabilize Your Thyroid.»

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The entire contents of this website are based upon the opinions of Dr. Richard Hagmeyer unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Hagmeyer and his community. Dr. Hagmeyer encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Hagmeyer products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products. Copyright © 2022 Dr. Hagmeyer · All Rights Reserved · Powered by drhagmeyer.com