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Types of Gluten Intolerance

Gluten intolerance is not as straight-forward as it may seem. Even though useful, traditional blood tests for gluten sensitivities only look at one component of gluten to determine if one is sensitive, alpha gliadin. It is very common for someone who is in fact gluten sensitive to test negative because he or she is does not respond to alpha gliadin.

Our unique test from Cyrex Labs (array #3) identifies 15 different components of wheat that can promote inflammation and negatively stimulate the immune system.

These reactions and lead to allergies, celiac disease, and other autoimmune diseases.


Gluten and the Brain

This test panel also looks for the potential for gluten to cause addictive behaviors. Specific enzymes in the gut break gluten down into opioids that promote addictive behaviors. One of the major reasons our society has seen a spike in ADD/ADHD, depression, anxiety and other neurological dysfunctions is because of these opioids.


The Many Components of Wheat Protein and Why We Test

Wheat/Gluten Sensitivity and Autoimmunity 1


Wheat/Gluten Proteome

reactivity & autoimmunity Antigens Tested (IgG and IgA tested separately for each antigen)

  1. Wheat
  2. Wheat Germ Agglutinin
  3. Non-Gluten Proteins-A*
  4. Non-Gluten Proteins-B*
  5. Gliadin Toxic Peptides*
  6. Native + Deamidated Alpha-Gliadin-33-mer
  7. Alpha-Gliadin-17-mer
  8. Gamma-Gliadin-15-mer
  9. Omega-Gliadin-17-mer
  10. Glutenin-21-mer
  11. Gluteomorphin+Prodynorphin
  12. Gliadin-Transglutaminase Complex• Microbial Transglutaminase*
  13. Transglutaminase-2
  14. Transglutaminase-3
  15. Transglutaminase-6

Wheat/Gluten Sensitivity and Autoimmunity 3


Frequently Asked Questions

Can a person test positive against one of the components of wheat but be negative for a response to the whole kernel of wheat?

Yes. Wheat is made up of many proteins and peptides. The immune response to the whole kernel may be limited, even if a patient is very reactive to the smaller proteins and peptides, such as glutenin or gluteomorphin

Are there any medications, foods, conditions, or other factors that could interfere with the results of a Cyrex Labs test?

Yes. While Cyrex Labs is unable to provide an exhaustive answer to this question due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:

a. Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results.
b. Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed.
c. Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex Labs has already developed Array 4 in order to recognize the most common antigens in this regard.
d. A gluten-free diet can cause false negative results on gluten protein/peptide tests.
e. Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.

1-Lian L, Remzi FH, Kiran RP, Fazio VW, Shen B. Clinical implication of false-positive celiac serology in patients with ileal pouch. Dis Colon Rectum. 2010 Oct; 53(10):1446-1451.


Why I use Cyrex Labs rather than another lab?

Researchers have proven that 50% of patients diagnosed with Celiac disease do not respond to the one protein being assessed in the conventional tests, instead they react to one or more of the other gluten proteins that are not measured in those conventional tests.  Additionally, more labs are switching to only offering deamidated gliadin because it is more sensitive for Celiac disease.

Unfortunately, the larger percentage of the population, Non-Celiac Gluten Sensitive patients, has been shown to be more reactive to native gliadin.  At Cyrex Labs both native and deamidated gliadin along with other gluten family proteins, the opioid peptides from both gluten and wheat, the lectin portion of wheat and wheat as a whole.

Because not every person’s gluten reactivity manifests as Celiac disease, Cyrex Labs measures antibodies to multiple transglutaminases to capture those patients whose gluten reactivity manifests as skin disorders or neurological complaints.

 

Wheat/Gluten Sensitivity and Autoimmunity 4